Endocrine Abstracts

The National Health Service and Nursing are currently facing challenging times. Continuing austerity measures combined with healthcare reform and a climate of professional uncertainty often results in nurses having to justify their existence.The quality, innovation, productivity and prevention (QIPP) initiative sets out how the National Health Service is to make efficiency savings whilst improving the quality of care that patients receive. With the appro...

11beta-Hydroxysteroid dehydrogenase (11beta-HSD) catalyses the interconversion of hormonally active cortisol (F) and inactive cortisone (E). 11beta-HSD1 is an NADP(H) dependent enzyme expressed in human liver and adipose that is targeted to the ER membrane with a lumenal catalytic domain. In vivo the enzyme acts predominantly as a reductase, generating F from E. The inherited condition, Apparent Cortisone Reductase Deficiency (ACRD) is a form of PCOS characterised by ACTH medi...